On November 5, 2019, Notch Therapeutics and Allogene Therapeutics announced a collaboration to research and develop induced pluripotent stem cell (IPSC)-derived allogeneic therapies for hematologic cancer indications. Allogene Therapeutics is taking a 25% stake in Notch Therapeutics and paying $10 million up front in an exclusive deal to research and develop new induced pluripotent stem cell (IPSC)-based allogeneic CAR T therapies, initially in non-Hodgkin lymphoma, leukemia and multiple myeloma. Notch Therapeutics, a Toronto-based immune cell therapy company creating universally compatible, allogeneic (off-the-shelf) T cell therapies for the treatment of diseases of high unmet medical need, stands to make millions of dollars more in milestone payments and royalties should any commercial products emerge from the collaboration.
Partners Steven Barrett and Brian Johnson led the WilmerHale team, which included Tim Kulis and Howell Ma.